In conclusion, SFN attenuated pancreatic damage by exerting antioxidant defensive activities through the Nrf2 pathway and anti-inflammatory effects by inhibition of NLRP3 inflammasome and NF-κB during AP (Figure 5). Brassica-derived isothiocyanate SFN may therefore represent a beneficial nutrient compound that can be used in managing AP. The gene discussed is NFE2L2; the disease is alkaline phosphatase measurement.