Recent findings indicate that the nucleotide-binding domain leucine-rich repeat containing family, pyrin domain-containing 3 (NLRP3) inflammasome, provides the link between acinar cell death and inflammation during the development of AP; and activation of NLRP3 inflammasome is involved in the development of AP [19], which is inhibited by antioxidants like hydrogen-rich saline [12]. This evidence concerns the gene NLRP3 and alkaline phosphatase measurement.