Finally, the effect of Notch3 in lung carcinoma has been observed to be strongly dependent on cell type being a tumor suppressor in Small Cell Lung Cancer (SCLC) and a tumor promoting in NSCLC by differentially modulating cell adhesion, Epithelial Mesenchymal Transition (EMT), and cell motility [36]. Here, NOTCH3 is linked to small cell lung carcinoma.