However, despite the overall similarity, the most relevant differences identified in SCLC-like LCNEC were an elevated rate of KEAP1-NFE2L2 mutations that rarely occur in conventional SCLC but are frequent in SqCC, suggesting a stronger histogenetic relationship of some conventional SCLCs and SqCCs [78]. The gene discussed is KEAP1; the disease is large cell neuroendocrine carcinoma.