KEAP1 and non-small cell lung carcinoma: A possible role of histone deacetylation/acetylation in the epigenetic regulation of the Keap1/Nrf2 pathway has been reported in human NSCLC, where hMOF-mediated acetylation of Nrf2 increased its nuclear retention and the transcription of its downstream genes, subsequently modulating tumor growth and drug resistance [122].