PIK3CA and non-small cell lung carcinoma: In NSCLC and malignant mesothelioma cells, the activation of PTEN transcription by Notch1 upregulation has been observed to lead the prosurvival phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway [29–32].