NFE2L2 and cancer: The large-scale genomic studies of NSCLC by The Cancer Genome Atlas (TCGA) consortium and others have supported that Nrf2 deregulation represents one of the major cancer driver pathways in the specific histotypes of SqCC where cigarette exposure can activate the oxidant stress response [76] and LCNEC of the lung with Non-Small-Cell Carcinoma features [77, 78].