By performing genome/exome and transcriptome sequencing Fernandez-Cuesta et al. have demonstrated that it is possible to distinguish an LCNEC SCLC-like group, carrying MYCL1 amplifications and mutations in both RB1 and TP53 genes from an AD/SQ-like group, harboring CDKN2A deletions, TTF1 amplifications, and frequent mutations in KEAP1 and STK11. Here, KEAP1 is linked to small cell lung carcinoma.