In NSCLC cell lines, it has been preliminary observed that the expression of the active form of Notch1 (NICD1) leads to increased proliferation activity, malignant transformation, and tumor growth in presence of EGF (Epidermal Growth Factor), suggesting that EGFR activation may be essential for Notch-mediated malignant transformation and tumor growth [25]. The gene discussed is NOTCH1; the disease is non-small cell lung carcinoma.