Three major crosstalks between Nrf2 and other classical oncogenic signaling pathways such as phosphatidylinositol 3-kinase (PI3K) [94], Kirsten retrovirus-associated DNA sequence (K-ras), [95] and Notch [4] have been reported in lung cancer as having a strong impact on tumor resistance outcome. The gene discussed is PIK3CA; the disease is lung cancer.