In NSCLC and malignant mesothelioma cells, the activation of PTEN transcription by Notch1 upregulation has been observed to lead the prosurvival phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway [29–32]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.