The experiments of Xu showed that sea cucumber saponin and polysaccharides from Pearsonothuria graeffei (Pg), Apostichopus japonicus (Aj), Cucumaria frondosa (Cf), and Isostichopus badionotus (Ib) could significantly lower SUA level in hyperuricemia mice induced by feeding yeast extract powder for 14 days, and all of the natural products could inhibit hepatic XOD and adenylate deaminase (ADA) activities. This evidence concerns the gene ADA and hyperuricemia.