They also proposed the role of endometrial intraepithelial carcinoma as a precursor to serous carcinoma whereby nine cases of serous carcinoma with an associated serous endometrial intraepithelial carcinoma had concordant PIK3CA, PP2R1A, and TP53 mutations (Kuhn et al., 2012). This evidence concerns the gene PIK3CA and serous adenocarcinoma.