There are studies demonstrating that a delayed expression of c-Fos occurred after a single challenge (Bing et al., 1997), that a peak of c-Fos expression appeared in 4–7 days in the brain and was connected with excitotoxic cell death (Smeyne et al., 1993) and that the biphasic induction of c-Fos expression was caused by diffuse brain injury (Zheng et al., 2014). The gene discussed is FOS; the disease is injury.