IL-15 enhanced CD56 MFI of NKT-like cells from SLE patients (1363 ± 79 versus 1199 ± 52, p = 0.001) and had no effect on controls (1218 ± 120 versus 1079 ± 67, p = 0.211). This evidence concerns the gene NCAM1 and systemic lupus erythematosus.