Previous study indicated that 10-H2DA suppression was likely to be mediated via blocking the p38 kinase and JNK-AP-1 signaling pathways and that 10-H2DA had no effect on ERK1/2, NF-κB DNA-binding activity, and IκBα degradation in TNF-α induced rheumatoid arthritis synovial fibroblasts [24]. This evidence concerns the gene MAPK8 and rheumatoid arthritis.