AKT1 and gastric cancer: Several signaling pathways, including the wnt/β-catenin, Notch, and PI3K/Akt pathways, have been found to be aberrantly activated and play vital roles in the development and progression of gastric cancer [11, 30, 31] Among these pathways, the functions of wnt/β-catenin signaling in gastric cancer development and progression have been well documented.