It has been reported that the pathway blocked by dickkopf WNT signaling pathway inhibitor 1 (DKK-1), naked cuticle homolog 1 (NKD1) and glycogen synthase kinase 3 beta (GSK3β) caused a robust reduction in the activity of wnt/β-catenin signaling and self-renewing capacity of gastric cancer cells [12–16]. Here, NKD1 is linked to gastric cancer.