However, expression levels of Beclin 1 were significantly higher in patients older than one year at diagnosis compared to younger patients (p < 0.001) (Table 1), in primary tumors than in metastasis (p < 0.01) and in standard NBs than in tumors coming from mass screening (p < 0.001), demonstrating that Beclin 1 is highly expressed in NB with poor prognosis. Here, BECN1 is linked to neuroblastoma.