We found that DGCA/MEGENA identified the most modules significantly enriched in genes associated with ER+ breast cancer and estrogen receptor (ER) signaling, while DGCA/MEGENA and DICER tied in the number of modules significantly enriched in TNBC genes, and DICER identified the most modules significantly enriched in the KEGG terms Cell Cycle and Mismatch Repair. This evidence concerns the gene ESR1 and breast carcinoma.