There are some studies that revealed genetic alterations in patients with uterine leiomyomas—a chromosomal rearrangement of 12q14-15 reflecting the rearrangement of the HMGA2 allele and a mutation of mediator complex subunit 12 (MED12), a transcription factor gene [14, 15]. Here, MED12 is linked to Uterine leiomyoma.