Serum ACE level was elevated in 238 of 674 patients (35%, 95% CI 32–39%), erythrocyte sedimentation rate was elevated in 64 of 202 patients (32%, 95% CI 25–38%), and hypercalcemia was present in 19 of 222 evaluated patients (9%, 95% CI 5–12%). The gene discussed is ACE; the disease is Hypercalcemia.