In the group of fetuses with the isolated increased nuchal translucency a small interstitial 16q24.1 deletion was identified, involving FOXF1 gene (Alveolar capillary dysplasia with misalignment of pulmonary veins, ACDMPV, OMIM#265380) and FOXC2 gene (Lymphedema-distichiasis syndrome, OMIM#153400). This evidence concerns the gene FOXC2 and alveolar capillary dysplasia with misalignment of pulmonary veins.