We subjected the three KRAS-mutant lung adenocarcinoma cell lines to STAT3 RNAi, and PD-L1 expression decreased in two of them, NCI-H1373 and NCI-H441, but not in NCI-H358 cells, at both protein and mRNA levels (Fig 5A and 5B). The gene discussed is KRAS; the disease is lung adenocarcinoma.