In this study, we also found that NAC significantly rescued AF-induced inhibition of ARPE-19 cells viability and blocked AF-induced down-regulation of total EGFR and up-regulation of phosphorylated EGFR, ERK, P38MAPK, JNK, MAPKAPK2, c-Jun, and HSP27. The gene discussed is JUN; the disease is atrial fibrillation.