In the last few years, several genome-wide association studies (GWAS) have revealed genetic variants associated with iron status in the general population, including common variants in the hereditary hemochromatosis gene (HFE), transferrin gene (TF), transferrin receptor and transferrin receptor 2 gene (TFRC, TFR2), solute carrier family 40 member 1 gene (SLC40A1), and transmembrane serine protease 6 gene (TMPRSS6) [9–14]. Here, TMPRSS6 is linked to hereditary hemochromatosis.