Table 1 describes the demographics of this cohort, which includes predominantly adolescents (median age 14). The median time from T1D onset was 13 days, and the majority of subjects (71%) had samples collected within 3 weeks of initiating insulin therapy. 90% of new onset T1D patients had ≥1 iAb present and 81% had ≥2 iAb present. As shown in Fig 3, serum measurements for each autoantibody significantly correlate with DBS measurements with R2 = 0.96 for mIAA, GADA 0.94, IA-2A 0.85, and ZnT8A 0.82. This evidence concerns the gene INS and type 1 diabetes mellitus.