While, patients with either CRKL or SLC7A5 over-expressed in tumor tissues exactly presented a tendency of large tumor size (P<0.05), deeper local invasion (P<0.05), much more frequent lymph node metastasis (P<0.05) and more advanced TNM stages (P<0.05), which indicated poor prognosis compared with the patients with relatively lower CRKL and SLC7A5 expression. Here, CRKL is linked to neoplasm.