In the present study, we modulated the expression of CRKL in SGC-7901 cells, and observed that the depletion of CRKL in gastric cancer SGC-7901 cells was companied with a down-regulation of SLC7A5 at both mRNA stage and protein stage, which suggests SLC7A5 as a downstream gene of CRKL. The gene discussed is SLC7A5; the disease is gastric cancer.