Accumulative evidences have indicated that SLC7A5 is essential for both normal and malignant cells to maintenance, and aberrant high expression of SLC7A5 has been observed in a variety of malignant cells than that in normal cells, including colon cancer, prostate cancer, pulmonary cancer and esophageal cancer [8–11]. The gene discussed is SLC7A5; the disease is esophageal cancer.