In fact, we found to the contrary that both NOX1 and NOXA1 were significantly downregulated in B group cancers (NOX1, FC = –2.3, Jorissen cohort; NOXA1, FC = 1.3, both cohorts), which further supports the idea that exogenous, bacterially-derived ROS is a driver in B group CRCs. Here, NOXA1 is linked to cancer.