BMI1 and colorectal carcinoma: In addition, BMI1 polycomb ring finger oncogene—an intestinal stem cell marker that is overexpressed in various cancers [23]–was upregulated two-fold in E. faecalis+ CRCs, which is striking since high expression of BMI1 is significantly associated with metastasis [24,25] and poor survival [26] in CRC patients.