Interestingly, REG1A is associated with poor prognosis in CRC [45], and recurrence and/or distant metastasis and short median survival in patients with MSI+ tumours [46]; it is noteworthy therefore that the upregulation of REG1A and REG3A seen here is specific to Fusobacterium-high tumours, rather than MSI+ tumours, with these genes being not significantly differentially expressed in MSI+ vs. MSI- tumours in our cohort. This evidence concerns the gene REG1A and neoplasm.