The WB analysis from each of the PCOS (n = 10) and control patients (n = 10) exhibited a significant (P<0.01) increase in the expression of PGRMC1, RBP1, HSP90B1, and CALM1 and a significant (P<0.05) decrease in the expression of ANXA6 and TPM2 in the ovary of PCOS in comparison to the control patients (S3B Fig). This evidence concerns the gene TPM2 and polycystic ovary syndrome.