Moreover, the AMPK kinase - a master regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells, mediates the “metabolic switch” from oxidative phosphorylation (OXPHOS) to glycolysis [53] and Pineda and Potts [52] recently demonstrated that TRIM28 together with MAGE-A3/6 proteins form a cancer-specific ubiquitinase that target AMPK for proteasomal degradation. This evidence concerns the gene TRIM28 and cancer.