Therefore, it is attractive to conclude that downregulation of TRIM28 may lead to accumulation of AMPK in cancer cells resulting in “metabolic switch” from oxidative phosphorylation (OXPHOS) to glycolysis (Figure 7A) and such metabolic dysregulation could be a reason for observed TRIM28-dependent inhibition of triple-negative breast tumor growth in vivo (Figure 8). This evidence concerns the gene TRIM28 and cancer.