EZH2 is also activated in many cancers, UTX, an H3K27me3 demethylase, is inactivated in multiple myeloma, esophageal, renal and bladder and in other cancers, the demethylase JMJD3 is expressed at very low levels therefore leads high level of H3K27me3 [72]. This evidence concerns the gene MBD2 and plasma cell myeloma.