Further analysis of the knowledge-based interactome surrounding the regulation of MAPK via IPA analysis demonstrated that CCL2, ATF4, MMP1, EGFR, CXCL1 FOSL2, JUN and p53, which have been implicated in the proliferation and metastasis of various cancers [26–30], were found to be differentially regulated by RPL34 (> 2-fold, P < 0.05). The gene discussed is ATF4; the disease is cancer.