By using generated polyclonal antibodies against Hyal-2 [21, 24], a 53-kDa protein is shown in breast cancer MCF7, neuroblastoma SK-N-SH, prostate cancer DU145, kidney fibroblast COS7 and L929 fibrosarcoma cells (Figure 4A). The gene discussed is HYAL2; the disease is Familial prostate cancer.