In the 53 Chinese ESCC patients (58% male; average age 58 yrs) studied by Su et al [18], the mean and median ATP1A1 tumor/normal ratios were 1.57 and 1.43 respectively, both significantly different from 1.00 (p < 0.0001) (Supplementary Figure S3). This evidence concerns the gene ATP1A1 and neoplasm.