To this end it was shown that intracerebral delivery of lentiviral vectors driving the expression of KLK6 reduced the accumulation of intracellular α-synuclein and ameliorated the neuropathology in a transgenic mouse model of dementia with Lewy bodies that overexpressed wt α-synuclein, although the mechanism underlying the beneficial effect of KLK6 was not investigated [21]. Here, SNCA is linked to dementia.