SPP1 and Cognitive impairment: Although differences in osteopontin were not found between AD and controls in another mass spectrometry assay, it was identified as a predictor of conversion from mild cognitive impairment to AD.44 Using mass spectrometry assays we have now found osteopontin to be elevated in AD in two independent cohorts and individuals with Lewy Body dementia, many of whom will have AD pathology, we suggest this is likely to be a real finding.