FKBP5 and post-traumatic stress disorder: Epigenetic modifications, including DNA methylation, histone modifications and ncRNAs, have been implicated in a number of complex diseases such as cardiovascular disease, cancer and neurological diseases.29 In regards to PTSD, the recently identified allele specific DNA methylation of FKBP5, a potential candidate gene for PTSD, has been suggested to mediate gene-childhood trauma interactions.30Table 1, summarizes reports of dysregulated miR in both preclinical and clinical models of PTSD.