CRHBP and substance dependence: This approach led to the selection of three SNPs located in the CRFBP(10 kD) gene regions: rs10055255 and rs10062367, which were previously evaluated in stress-induced alcohol craving in heavy drinkers;26 and rs7728378, which was previously investigated in Caucasian alcohol dependent individuals.27 Notably, the latter SNP was associated with suicide attempt in another study of patients with alcohol and substance dependence.28 Only rs10062367 was present in our dataset.