We a priori selected single-nucleotide polymorphisms (SNPs) of the CRHBP gene that are located in gene regions related to CRFBP(10 kD), an approach driven by the chimeric results reported above and were investigated for possible association with alcoholism in previous studies,26, 27 an approach driven by the rodent results reported above. The gene discussed is CRHBP; the disease is alcohol drinking.