CRHBP and Anxiety: In particular, CRF binds both CRFR1 and CRFR2α, but is more potent at CRFR1.14, 15, 16, 17 Interestingly, there is ample evidence that CRFR1 is associated with anxiety-related behaviors.18, 19 In light of this, we examined whether the observed enhancement of the CRFBP(10 kD) chimeric complex signaling was specific to CRFR2α or whether the expression of CRFR1 would also increase signaling in a chimeric protein when tethered with CRFBP(10 kD).