Thus, PI3K-Akt-mTOR signalling is important both for aging, adaptation, differentiation, communication and proliferation of BM MSCs, and even though the molecular mechanisms are only partly known, one would expect PI3K-Akt-mTOR inhibition to alter the MSC functional characteristics and thereby also affect the AML cell microenvironment including that of the stem cell niches. This evidence concerns the gene AKT1 and acute myeloid leukemia.