Importantly, in silico analysis revealed the existence of distinct miRNA expression profiles, distinguishing OA from RA; even in the case that a single molecule (e.g., the transcription factor Ets-1) is predicted to be commonly targeted by miRNAs that display differential expression in OA and RA, this commonly-regulated molecule is postulated to be implicated in the pathogenesis of these different arthropathies through the modulation of different proteins [63]. The gene discussed is ETS1; the disease is rheumatoid arthritis.