PIAS3 and atherosclerosis: To explore the correlation between PIAS3 and atherosclerosis further, we conducted experiments with proinflammatory cytokine IL-6, which is highly expressed in atherosclerotic aortas and can directly activate gp130/JAK/STAT3 signalling to exacerbate atherosclerosis by promoting cell inflammation, proliferation, differentiation and migration9, 10.