Besides, the proliferative rate was about 10–20% in MCF-10AT group assessed by Ki67 staining (Fig. 5d), while Ki67 was relatively higher expressed (20–30%) in the hotspot of tumor cells in MCF-7 group and a lot of mitotic figures were identified (Fig. 5e), indicating the active tumor proliferation. This evidence concerns the gene MKI67 and neoplasm.