However, patients with breast cancer were reported to display a higher plasma TrxR1 activity compared with those with breast hyperplasia in all three age groups (Pre-menopause: P value = 0.0456, Z value = 0.02; Perimenopause: P value = 0.0168, Z value = 2.39; Post-menopause: P value = 0.0088, Z value = 2.62) (Table 1). The gene discussed is TXNRD1; the disease is breast cancer.