BBSKE not only inhibited TrxR1 activity in MCF-7 and MCF-10AT cells but also decreased the expression of other tumor-related proteins (i.e. Trx, N-Cadherin) in MCF-7 cells and increased E-Cadherin protein level in MCF-10AT cells, further supporting TrxR1 involvement in the pathogenesis of breast cancer. The gene discussed is CDH1; the disease is breast carcinoma.