It was found that the rs2735383CC genotype significantly decreased the expression of the NBS1 gene through either binding of microRNA-629 to the 3′-UTR of NBS1 gene in lung cancer cells or the binding of microRNA-509-5p to the 3′-UTR of NBS1 gene in colorectal cancer cells19, 20. This evidence concerns the gene NBN and colorectal cancer.