The functional variant rs2735383, localized in in the 3′ UTR of NBS1, has been shown to modulate the binding ability of microRNA-629 in lung cancer cells and microRNA-509-5p in colorectal cancer cells, affect NBS1 transcriptional activity and decrease NBS1 mRNA and NBS1 protein levels19, 20. The gene discussed is NBN; the disease is colorectal cancer.