The CC genotype of the common variant rs2735383 in the 3′UTR of NBS1 has been shown to be associated with an increased cancer risk, specifically for lung and colorectal cancer (lung cancer: OR = 1.28, 95% CI = 1.21–1.46, P < 0.001 and colorectal cancer: OR = 1.55, 95% CI = 1.27–1.94, P < 10−4)13, 20. The gene discussed is NBN; the disease is colorectal cancer.