Her-2, EGFR, TOPIIα, P170, Ki67, CA199, CEA, ERCC1, MLH1, MSH2, CDX2, nm23, PTEN and survivin are routine pathological molecular markers that are evaluated by immunohistochemistry in the department of pathology as required to diagnose CRC (Fig. 4). Here, MSH2 is linked to colorectal carcinoma.