Her-2, EGFR, TOPIIα, P170, Ki67, CA199, CEA, ERCC1, MLH1, MSH2, CDX2, nm23, PTEN and survivin are routine pathological molecular markers that are evaluated by immunohistochemistry in the department of pathology as required to diagnose CRC (Fig. 4). The gene discussed is TOP2A; the disease is colorectal carcinoma.