However, pre-treatment of BEL7402 and HepG2 cells with the JNK inhibitor, SP600125, significantly enhanced BafA1-induced cell death (Fig. 6B), suggesting that a combination of BafA1 with a JNK inhibitor may be a potential strategy to enhance the effects of BafA1 in mediating HCC cell death. The gene discussed is MAPK8; the disease is hepatocellular carcinoma.