A second area of safety concern is with increased risk of intracerebral haemorrhage as seen in other trials of colony stimulating factors (erythropoietin)35, though there is conflicting preclinical literature as to whether G-CSF attenuates or potentiates risk of haemorrhage when used in conjunction with thrombolysis36, 37. The gene discussed is CSF3; the disease is intracerebral hemorrhage.