Consistent with the previous smaller MR study using five SNPs for coffee18, we found little evidence of coffee being clearly related to T2DM or major CVD risk factors (HDL-cholesterol, LDL-cholesterol, triglycerides and BMI), although we cannot rule out the possibility of coffee raising LDL-cholesterol, BMI, WHR and adiponectin. Here, ADIPOQ is linked to type 2 diabetes mellitus.