Notably, the immunoblot analysis of p-RPA in normal human controls (NHA-DRB, BJ) and the four non-GBM cancer cell lines (OVCAR5, Cal51, PC3 and HELA) confirmed elevated p-RPA levels after BRCA1 knockdown (Supplementary Figs 1d and 2c). The gene discussed is RPA1; the disease is glioblastoma.