We have shown that haploinsufficiency for Pten leads to dysregulation of a disease-implicated signalling pathway (the mTOR signalling pathway) that regulates neuronal connectivity, and altered connectivity in an autism-relevant neural circuit (mPFC-amygdala) affects activity in a key brain region (amygdala) in response to social cue, as well as social behaviour. Here, PTEN is linked to autism.