In this retrospective cross-sectional study, only VDRA administration was found to be independently associated with a significantly reduced risk of either uremic nausea or all uremic symptom development, adjusted by CKD-MBD-associated factors, such as corrected calcium, phosphorus, intact PTH, and CaCO3 administration, and nephrologist follow-up period. The gene discussed is PTH; the disease is Marchiafava-Bignami disease.