Although the regulatory actions of leptin on energetics and food intake have been extensively reported, emerging data support its importance in neural development and plasticity (Dhar et al., 2014), hippocampal function, and psychiatric disorders (Sharma et al., 2010; Guo et al., 2013; Tyree et al., 2016), including PTSD (Liao et al., 2004; Farr et al., 2015). The gene discussed is LEP; the disease is post-traumatic stress disorder.