Although whether BLA CRFR1 activation precisely reflects the CS-related degree of amygdalar excitation remains to be established, intra-BLA CRF infusions were shown to lead to robust increases in anxiety behaviors (Sajdyk et al., 1999) and to induce long-lasting sensitization of noradrenergic substrates and PTSD-like symptoms (Rajbhandari et al., 2015) in rodents. The gene discussed is CRHR1; the disease is Anxiety.