CRH and Anxiety: To determine whether AMPA GluA1 Ser845 phosphorylation levels were modulated by the actions of CRF after fear conditioning, we examined phosphorylation in the amygdala in animals infused with either vehicle or NBI30775 and sacrificed after an extinction session delivered 30 min postconditioning (Fig. 5A) in groups balanced for their a priori anxiety-like behavior on the EPM (F(2,27) = 0.004; p = 0.99jj; Fig. 5B).