Methylsulfonylmethane (MSM) is an organosulfur compound that is widely used as a dietary supplement for inflammatory conditions such as osteoarthritis [4] and allergic rhinitis [5]. In vitro studies indicate that the anti-inflammatory activity of this compound is mediated by the inhibition of the proinflammatory nuclear factor kappa beta (NF-κβ) signaling pathway and attenuation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome activation, resulting in decreased release of the proinflammatory cytokines such as interleukins IL-1β, IL-6, and IL-8 [6–8]. This evidence concerns the gene NLRP3 and osteoarthritis.