In another study by Silva et al. [36], a group of five genes i.e., runt-related transcription factor 3 (RUNX3), protocadherin 10 (PCDH10), secreted frizzled-related protein 5 (SFRP5), insulin-like growth factor 2 (IGF2) and hepatocyte nuclear factor 1β (Hnf1b) were found to be having highest percentage of methylation within their promoter regions and consequently with highest repression of gene expression in CRC patients. The gene discussed is IGF2; the disease is colorectal carcinoma.