Among the most potential diagnostic biomarkers for CRC, the tumor specific M2 isoform of pyruvate kinase (PKM2) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), vimentin (VIM) and septin 9 (SEPT9) take a lead in being the most extensively investigated ones [17]. The gene discussed is PKM; the disease is colorectal carcinoma.