Tanzer et al., [40] observed that serum methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, aristaless-like homeobox 4 (ALX4) and SEPT9. They observed a significantly higher frequency of ALX4 and SEPT9 methylated DNA in plasma from patients with polyps as well as colorectal adenomas versus healthy controls. This evidence concerns the gene SEPTIN9 and colorectal adenoma.