HLTF and colorectal cancer: Wallner et al., [38] in their multivariate analysis identified three methylation markers: helicase-like transcription factor (HLTF), hyperpigmentation, progressive 1/transmembrane protein containing epidermal growth factor and follistatin domain (HPP1/TPEF), and hMLH in serum of colorectal cancer patients to be independently associated with poor outcome and a relative risk of death.