Lee et al., [29] identified another set of biomarkers i.e., O-6-methylguanine-DNA methyltransferase (MGMT), Ras association (RalGDS/AF-6) domain family member 2 (RASSF2A), and Wnt inhibitory factor 1(Wif-1) genes for the early detection of CRC. This evidence concerns the gene WIF1 and colorectal carcinoma.