Kim et al., [19] have also identified ten gene biomarkers: alcohol dehydrogenase, iron containing 1 (ADHFE1), Boule-like RNA-binding protein (BOLL), SLC6A15, ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5), TFPI2, eyes absent homolog 4 (EYA4), NPY, twist family BHLH transcription factor 1 (TWIST1), laminin, alpha 1 (LAMA1), and growth arrest-specific 7 (GAS7) and two genes: maelstrom spermatogenic transposon silencer (MAEL), SFT2 domain containing 3 (SFT2D3) showing hypomethylation in CRC tissues. The gene discussed is ADAMTS5; the disease is colorectal carcinoma.