SFRP5 and colorectal carcinoma: In another study by Silva et al. [36], a group of five genes i.e., runt-related transcription factor 3 (RUNX3), protocadherin 10 (PCDH10), secreted frizzled-related protein 5 (SFRP5), insulin-like growth factor 2 (IGF2) and hepatocyte nuclear factor 1β (Hnf1b) were found to be having highest percentage of methylation within their promoter regions and consequently with highest repression of gene expression in CRC patients.