ALX4 and colorectal adenoma: Tanzer et al., [40] observed that serum methylated DNA from advanced precancerous colorectal lesions can be detected using a panel of two DNA methylation markers, aristaless-like homeobox 4 (ALX4) and SEPT9. They observed a significantly higher frequency of ALX4 and SEPT9 methylated DNA in plasma from patients with polyps as well as colorectal adenomas versus healthy controls.