Recent studies have elucidated the relevance of KLOTHO promoter hypermethylation in colorectal carcinoma in humans [9, 15].This study was aimed to analyze the promoter hypermethylation of KLOTHO gene and correlate this epigenetic change with various clinico-histopathological parameters in subjects with colorectal carcinoma. Here, KL is linked to colorectal carcinoma.