CDX2 and neoplasm: Based on two studies miR-9 is down-regulated in gastric carcinoma and has tumor suppressor activity by NF-κB1 expression regulation [18-19], but recently it has been reported that miR-9 is up-regulated in gastric cancer tissues and down-regulated CDX2 expression but methylation status of these three miR-9 regions did not correspond to the expression levels of precursor miR-9 or maturemiR-9 [34].