In the IFN-free regimen the presence of Q80K was associated with treatment failure only in a small sample size of patients with genotype 1a and cirrhosis: a phase 3 study (OPTIMIST-2) evaluated the efficacy and safety of 12 weeks of simeprevir plus sofosbuvir in HCV genotype 1 infected treatment-naïve or treatment-experienced patients with cirrhosis. This evidence concerns the gene IFNA1 and Cirrhosis.