Because immune responses are usually involved in the process of viral infection, many immune-related genes such as CD40 ligand (CD40LG), interleukin 6 receptor (IL-6R), interferon regulatory factor 4 (IRF4), and toll-like receptor 10 (TLR10) were predicted, all of which might participate in host antiviral responses against CVA16 and EV71. The gene discussed is TLR10; the disease is viral infectious disease.