In particular, quercetin may potentiate p53-dependent apoptosis in melanocytic cells via stimulation of nuclear factor E2-related factor 2 (Nrf2) transcriptional activity, which has been observed in various cell types including human hepatoblastoma HepG2 cells (85, 86), human BJ foreskin fibroblasts and skin HaCaT keratinocytes (87), rat DI TNC1 astrocytes (88), and UVA-irradiated mouse B16F10 melanoma cells (89). This evidence concerns the gene NFE2L2 and melanoma.