NFE2L2 and melanoma: Quercetin has been demonstrated to induce Nrf2-mediated ARE activation in vitro in human hepatoblastoma HepG2 cells (85, 86), human BJ foreskin fibroblasts and skin HaCaT keratinocytes (87), rat DI TNC1 astrocytes (88), and UVA-irradiated mouse B16F10 melanoma cells (89).